2021-06-27 20:34
Virus-like particle (VLP) is a polymeric nanostructure assembled from natural viral structural proteins, but do not contain any genetic material. The VLP consists of high-density displays of viral surface proteins and is therefore a highly adaptable
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2021-06-27 20:34
A number of computational methods have been used in various aspects of drug discovery and development. In recent decades, in silico ADMET (absorption, distribution, metabolism, excretion, and toxicity) modeling as a rational drug design tool has rece
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2021-05-19 10:54
Over the past five years, the world has experienced several outbreaks of virus, including Ebola virus, Zika virus, MERS-CoV and SARS-CoV-2 (novel coronavirus, formerly termed as 2019-nCoV). Faced with the potential threat of a pandemic, research inst
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2021-05-19 10:53
Proteins are the executors of coronavirus infection in host cells. To understand the functions of specific proteins during infection, we need to study many aspects of proteins, such as protein interactions, protein modifications, and three-dimensiona
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2021-05-19 10:53
The analysis of three-dimensional (3D) structure is of great importance for the mechanism of virus infection and the design of antiviral drugs. Although many breakthroughs have been made in structural biology techniques and structure determination me
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2021-05-19 10:52
Coronaviruses (CoVs) pose a major threat to public health security because no drugs or vaccines are currently approved for the treatment of human CoVs. With the continuous outbreak of SARS-CoV-2 (novel coronavirus, formerly 2019-nCoV), how to rapidly
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2021-05-19 10:52
Protein-protein interactions (PPIs) are established when two or more proteins physically contact with each other. This phenomenon leads to specific biochemical events, such as molecular transport, signal transduction, and various metabolic pathways.
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2021-05-19 10:52
Determining the three-dimensional (3D) structure of proteins is critical for understanding the mechanism of coronavirus infection, discovering potential drug targets and structure-based drug design. Rapid advances in methodologies for protein express
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2021-05-19 10:52
Since December 2019, multiple cases of pneumonia with unknown etiology have been found in Wuhan, China for the first time. The World Health Organization (WHO) eventually terms the pneumonia as Coronavirus Disease 2019 (COVID-19), and the novel corona
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