2021-09-24 07:41
Over the past five years, the world has experienced several outbreaks of virus, including Ebola virus, Zika virus, MERS-CoV and SARS-CoV-2 (novel coronavirus, formerly termed as 2019-nCoV). Faced with the potential threat of a pandemic, research inst
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2021-09-24 07:41
Protein-protein interactions (PPIs) are established when two or more proteins physically contact with each other. This phenomenon leads to specific biochemical events, such as molecular transport, signal transduction, and various metabolic pathways.
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2021-09-24 07:40
Determining the three-dimensional (3D) structure of proteins is critical for understanding the mechanism of coronavirus infection, discovering potential drug targets and structure-based drug design. Rapid advances in methodologies for protein express
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2021-09-24 07:40
The rapid development of instrument and data processing technology, especially the invention of electron microscopy, has brought great help to obtain the ultrastructure of viral particles. Equipped with state-of-the-art optical microscopy, electron m
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2021-09-24 07:40
The outbreak of Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2 (novel coronavirus, provisionally named 2019-nCoV) has occurred in many countries around the world. The virus can be identified in a short time thanks to high-throughput sequenc
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2021-09-24 07:37
Since December 2019, multiple cases of pneumonia with unknown etiology have been found in Wuhan, China for the first time. The World Health Organization (WHO) eventually terms the pneumonia as Coronavirus Disease 2019 (COVID-19), and the novel corona
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2021-08-26 06:25
The three-dimensional (3D) reconstruction technology of single-particle cryo-electron microscopy (cryo-EM) involves a complex image processing process from two-dimensional (2D) projection images to a 3D reconstruction model. Creative Biostructure cur
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2021-08-26 06:24
The latest technological advances in sample preparation, algorithm, and detector have made single-particle cryo-electron microscopy (cryo-EM) analysis a popular approach for solving macromolecular structures at near-atomic-resolution. After obtaining
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2021-08-26 06:24
The quality of X-ray diffraction data of the protein crystal can determine the success rate of the subsequent steps of structure determination and the reliability of the reconstructed three-dimensional (3D) structural model. After successfully obtain
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