2021-07-21 10:58 Negative stain electron microscopy (EM) is a technology that provides nanometer-resolution images of biological macromolecules. At present, the main role of negative stain EM in protein structural analysis is to construct an initial model and to conduct preliminary screening of samples before cryo-electron microscopy (Cryo-EM) observation. By applying the advances in cryo-EM image processing technology to the analysis of negative staining EM images, we can determine domain-level molecular structures (~10 Å) faster and more efficiently. Creative Biostructure currently supports the structural analysis of proteins and protein complexes involved in the process of coronavirus infection using negative staining EM.
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