2020-10-31 15:55 Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by age-related amyloid-beta (Aβ) deposition neurofibrillary tangles, and synapse and neuronal loss. Currently, only few drugs have been approved for the treatment of AD and impact the symptoms rather than disease progression. By the identification of genes that are related to AD, several gene therapy strategies for AD have been proposed, such as the use of adeno-associated virus 2 (AAV2) mediated nerve growth factor (NGF) gene transfer through the blood-brain barrier. Lentvirus mediated CRTC-1 overexpression in the hippocampus efficiently reverses Aβ-induced spatial learning and memory deficits. Empowered by first-class platforms and rich experience in the field of gene therapy, Creative Biolabs now provides one-stop custom-oriented service for your research to speed up the projects for academic and clinical purposes.
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