2020-12-21 20:41 CircRNA is a novel member of the non-coding RNAs (ncRNAs), generated by non-sequential backsplicing of exons, introns or both. They are characterized by covalently closed loop feature thus lacking 5’ end caps and 3’ poly-A tails. CircRNAs are highly stable forms of ncRNAs due to their nuclease resistance properties. When first identified in the 1970s, circRNAs were regarded as viral genomes or byproducts of mis-splicing events. But the recent researches have revealed that circRNAs are evolutionarily conserved across plants, animals, and human beings, and that circRNAs have important biological functions.