2021-07-21 10:58
The latest technological advances in sample preparation, algorithm, and detector have made single-particle cryo-electron microscopy (cryo-EM) analysis a popular approach for solving macromolecular structures at near-atomic-resolution. After obtaining
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2021-07-21 10:58
Negative stain electron microscopy (EM) is a technology that provides nanometer-resolution images of biological macromolecules. At present, the main role of negative stain EM in protein structural analysis is to construct an initial model and to cond
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2021-07-21 10:58
Creative Biostructure provides a complete contract crystallography service to support coronavirus infection-related research, including gene-to-structure pipelines at all stages from protein expression to structure determination. After successfully o
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2021-07-21 10:57
The quality of X-ray diffraction data of the protein crystal can determine the success rate of the subsequent steps of structure determination and the reliability of the reconstructed three-dimensional (3D) structural model. After successfully obtain
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2021-06-27 20:37
Scanning electron microscopy (SEM) is characterized by simple sample preparation, wide adjustable magnification range, high image resolution, and large depth of field. SEM technology can scan the surface morphology of the sample by emitting a bright
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2021-06-27 20:36
High-resolution microscopy is essential for visualizing viral particles, and the acquisition of morphological characteristics of viral particles depends on the resolution. Transmission electron microscopy (TEM) is the starting point for obtaining the
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2021-06-27 20:36
Cryo-electron tomography (cryo-ET) is an approach for resolving polymorphic structures such as cells and organelles in a near-natural state and can provide a three-dimensional (3D) snapshot of viral particles in the host cell environment. The cryo-el
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2021-06-27 20:36
Because viral particles are generally small (between tens and hundreds of nanometers in diameter), the traditional optical microscope is difficult to meet the needs of their morphological observation, which makes high-resolution electron microscopy (
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2021-06-27 20:35
The ongoing outbreak of novel coronavirus (also termed as SARS-CoV-2) poses a challenge for public health. There is an urgent need to understand the molecular mechanism of this viral infection and to develop effective vaccines and antiviral drugs on
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