2021-09-24 02:13
Among small molecule drugs, such as small RNAs, oligonucleotides, peptides or vaccines, recombinant proteins are the most commonly. The discovery and development of protein therapeutics is growing rapidly because of their cell-specific modality and r
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2021-09-24 02:12
The 1H (proton) NMR spectra are one of the most common NMR experiments. Apart from the tritium, the proton is the most sensitive nucleus and usually yields sharp signals. Proton NMR is very useful depending on its sharp signals even though its chemic
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2021-09-24 02:12
The overall three-dimensional shape of an entire protein molecule is the tertiary structure. The protein molecule will bend and twist in such a way as to achieve maximum stability or lowest energy state. Although the three-dimensional shape of a prot
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2021-09-24 02:12
Fluorescence has two distinct stages, excitation stage and emission stage. It is a phenomenon where fluorescent chromophore absorbs a light photon, typically remains in an excited state for a few nanoseconds and then emits a lower energy photon. Both
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2021-09-24 02:12
First introduced by Kaj Ulrik Linderstrom-Lang at Stanford in 1952, protein secondary structure is the three dimensional form of local segments of proteins and refers to the pattern of hydrogen bonds between the carboxyloxygen atoms and amino hydroge
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2021-09-24 02:12
Although electrophoresis, chromatography, and mass spectrometry offer widespread knowledge of molecular characteristics, the precise dimensional layout of atoms and the length of chemical bonds is still undetectable, unless by using more complex tech
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2021-09-24 02:11
Hydrogen–deuterium exchange, also called H–D or H/D exchange, is a chemical reaction, which can be used most easily to exchangeable protons and deuterons without any catalyst but in the presence of a suitable deuterium source. This often causes perde
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2021-09-24 02:11
Fourier-transform infrared spectroscopy (FTIR), often simply referred to as FTIRs, is used to gain an infrared spectrum of absorption or emission of a solid, liquid or gas. An FTIR spectrometer can gathers high-spectral-resolution data over a wide sp
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2021-07-21 12:00
The molecular weight of protein is an important analytical parameter in biochemistry. It is necessary to determine the molecular weight of recombinant proteins and key subunits by a fast and accurate method. Accurate quality determination allows us t
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