2022-01-29 23:12 E3 ligase Ligand-Linker Conjugates 14 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
2022-01-29 23:12 MAL-PEG-(γ)PGA is a copolymer with MAL at one end and PGA at the other end. It is a solid or semisolid which depends on its molecular weight.
2022-01-29 23:12 Bromo-PEG2-alcohol is a PEG linker containing a bromide group. The bromide can be replaced by nuleophilic reagents for bioconjugation and PEGylation.
2022-01-29 23:12 Bromo-PEG1-azide is a heterobifunctional PEG linker containing a bromide group and an azide group. The bromide can be replaced by nuleophilic reagents for bioconjugation and PEGylation,
2022-01-29 23:10 The 2'-O-methylated derivative of pesudoUridine has been observed in tRNAs of archaea and eukaryotes, in the 18+26S rRNA of eukaryotes, and in snRNAs in eukaryotes.
2022-01-29 23:10 2'-DeoxypseudoUridine belongs to the C-glycosides that linked by C-C bond rather than usual C1-N1 bond found in uridine. Especially, glycosidic bond of 2'-deoxypseudoUridine is that C-C bond between C5 of uracil and C1 of the deoxyribose sugar.