2021-09-24 07:41
Protein-protein interactions (PPIs) are established when two or more proteins physically contact with each other. This phenomenon leads to specific biochemical events, such as molecular transport, signal transduction, and various metabolic pathways.
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2021-09-24 07:40
Determining the three-dimensional (3D) structure of proteins is critical for understanding the mechanism of coronavirus infection, discovering potential drug targets and structure-based drug design. Rapid advances in methodologies for protein express
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2021-08-26 06:24
The necessary condition for successful X-ray crystallographic analysis is to obtain a single crystal of the target protein that meets the X-ray diffraction standard. The data are then collected by X-ray diffraction from a single crystal with an order
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2021-07-21 10:58
Negative stain electron microscopy (EM) is a technology that provides nanometer-resolution images of biological macromolecules. At present, the main role of negative stain EM in protein structural analysis is to construct an initial model and to cond
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2021-05-19 10:53
Proteins are the executors of coronavirus infection in host cells. To understand the functions of specific proteins during infection, we need to study many aspects of proteins, such as protein interactions, protein modifications, and three-dimensiona
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2021-04-22 21:12
The necessary condition for successful X-ray crystallographic analysis is to obtain a single crystal of the target protein that meets the X-ray diffraction standard. The data are then collected by X-ray diffraction from a single crystal with an order
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2021-04-02 06:32
Protein structure is significant to its function, so protein structure prediction is an important part of bioinformatics analysis for protein. To perform biological functions normally, protein molecules fold into one or more spatial conformations dri
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2021-04-02 06:32
The human coronavirus pandemic poses a huge threat to global public health and the economy; however, no vaccine or specific antiviral drug has yet been approved to treat Coronavirus Disease 2019 (COVID-19) pneumonia. Therefore, the development of pre
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2021-01-28 18:05
Proteins are highly adaptable and can evolve novel functions and structures. In fact, examples of the evolutionary fitness of proteins can be found everywhere, such as the numerous proteins originating from a common ancestor in nature, as well as dru
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