2021-05-19 11:22 Isoelectric point (pI) is one of the important physio-chemical parameters of macromolecules, which represents the pH when the overall net charge equals zero. The net charge of a particular molecule can be affected by the pH of surrounding environment, and the molecule can be more positively or negatively charged through the loss or gain protons. In addition, the pI of a molecule can influence the solubility its solubility at a certain pH and its overall pharmacokinetic behavior. Hence, it's essential to determine the pI of pharmaceutical products. Creative Proteomics will provide you with accurate and rapid pI determination according to ICH Q6B guidelines during drug development.
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