2021-01-28 18:10 There are multiple modes of interaction between gold nanoparticles and proteins, including physical adsorption, chemical covalent binding, and non-covalent specific adsorption. Click chemistry can covalently connect gold nanoparticles and proteins, or catalyze the reaction between nanoparticles, to obtain reaction results that can be read with the naked eye. The interaction between gold nanoparticles and proteins and the spectral properties of gold nanoparticles can be used for simple, efficient and low-cost detection of disease or environmental pollution, as well as for disease treatment.